Any Side Effects with Wegovy®?

Wegovy, a brand name for semaglutide, is a medication approved for chronic weight management. It works by mimicking the effects of the hormone GLP-1 (glucagon-like peptide-1), which helps regulate appetite and food intake. While Wegovy has shown significant efficacy in helping patients lose weight, it is essential to be aware of its potential side effects.

Wegovy® Side Effects

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Common Side Effects

Gastrointestinal Issues: The most frequently reported side effects of Wegovy are gastrointestinal in nature. Patients often experience nausea, vomiting, diarrhea, constipation, and abdominal pain. These symptoms are usually mild to moderate and tend to occur when starting the medication or increasing the dose. For many, these side effects diminish over time as the body adjusts to the drug.

Hypoglycemia: Especially in individuals with type 2 diabetes who are also taking medications such as insulin or sulfonylureas, there is an increased risk of hypoglycemia (low blood sugar). Symptoms of hypoglycemia include sweating, dizziness, confusion, and rapid heartbeat. It is crucial for patients and healthcare providers to monitor blood sugar levels closely and adjust diabetes medications as necessary.

Injection Site Reactions: Since Wegovy is administered via a subcutaneous injection, some patients may experience reactions at the injection site. These can include redness, swelling, or irritation. These reactions are generally mild and resolve on their own.

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Serious Side Effects

Pancreatitis: Although rare, there is a potential risk of developing pancreatitis (inflammation of the pancreas). Symptoms include severe abdominal pain, nausea, and vomiting. Patients should seek immediate medical attention if they suspect pancreatitis, as it can be a serious and potentially life-threatening condition.

Gallbladder Disease: Wegovy may increase the risk of gallbladder problems, including gallstones and cholecystitis (inflammation of the gallbladder). Symptoms of gallbladder issues include upper abdominal pain, fever, and jaundice (yellowing of the skin and eyes). If these symptoms occur, medical evaluation is necessary.

Kidney Injury: Dehydration due to gastrointestinal side effects like vomiting or diarrhea can potentially lead to acute kidney injury. It is essential for patients to maintain adequate hydration and seek medical help if they experience prolonged vomiting or diarrhea.

Increased Heart Rate: Some patients may experience an increase in heart rate while taking Wegovy. Regular monitoring of heart rate is recommended, and patients should report any significant changes or symptoms such as palpitations or dizziness to their healthcare provider.

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Psychological Effects

Mood Changes: Some patients have reported mood changes, including depression and anxiety. While these are not common, they can be significant for those affected. It is important for patients to communicate any psychological symptoms to their healthcare provider.


Wegovy offers a promising option for weight management, but like all medications, it comes with potential side effects. Patients should be fully informed about these risks and work closely with their healthcare providers to monitor and manage any adverse effects. Regular follow-ups and open communication can help maximize the benefits of Wegovy while minimizing its risks.


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