
Semaglutide Weight Loss Injections
Semaglutide, originally developed for the treatment of type 2 diabetes, has also been approved for weight management under the brand name Wegovy. Its efficacy in weight loss has been compared to other weight loss injections such as liraglutide (Saxenda), and here’s how they generally stack up…

Wegovy Weight Loss
Semaglutide (Wegovy)
- Dosage: Weekly
- Average Weight Loss: Clinical trials have shown an average weight loss of around 15-20% of initial body weight over a period of 68 weeks.
- Mechanism: Semaglutide is a GLP-1 receptor agonist, which mimics the GLP-1 hormone that targets areas of the brain involved in regulating appetite and food intake.
- Side Effects: Common side effects include nausea, diarrhea, constipation, vomiting, and abdominal pain. These tend to decrease over time.
Liraglutide (Saxenda)
- Dosage: Daily
- Average Weight Loss: Clinical trials have shown an average weight loss of around 5-10% of initial body weight over a period of 56 weeks.
- Mechanism: Like semaglutide, liraglutide is also a GLP-1 receptor agonist, but it requires daily injections.
- Side Effects: Common side effects include nausea, diarrhea, constipation, vomiting, and low blood sugar. These also tend to decrease over time.
Here are some more things to look for:
While comparing semaglutide and liraglutide specifically, semaglutide shows a higher efficacy in weight loss, largely due to its longer half-life and less frequent dosing schedule, which might contribute to better adherence and more sustained effects.
Other Weight Loss Injections
Setmelanotide (Imcivree): Approved for specific genetic conditions causing obesity, this medication has shown varying degrees of weight loss depending on the condition being treated.
Phentermine/Topiramate (Qsymia): While not an injection, this combination oral medication is another effective option for weight loss, leading to an average weight loss of 5-10% of initial body weight over a year.
Summary
Semaglutide (Wegovy) tends to show superior efficacy compared to liraglutide (Saxenda) and other available weight loss injections, with a more convenient dosing schedule and higher average weight loss percentages. However, the choice of medication can depend on individual patient factors, including other health conditions, side effect profiles, and personal preferences.
Semaglutide
- 1ml/2.5mg
Semaglutide
- 3ml/12.75mg
Tirzepatide
- 50mg/5ml

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