semaglutide glp-1

Semaglutide Absorption – Pills vs. Injections

Yes, there is a significant difference in the absorption of semaglutide between injections and pills:


Semaglutide injectable forms bypass the digestive system altogether, delivering the medication directly into the bloodstream. This results in near-complete absorption and predictable drug effects.


Oral semaglutide needs to pass through the stomach and intestines, where it can be broken down by enzymes and have limited absorption.
To overcome this challenge, oral semaglutide is co-formulated with a special ingredient called sodium N-(8-[2-hydroxybenzoyl]amino) caprylate (SNAC).
SNAC helps protect semaglutide from degradation and allows it to be absorbed through the stomach lining.

However, food significantly hinders the absorption of oral semaglutide. Studies show that taking it with food can lead to no measurable drug exposure in some individuals and reduced effectiveness in others.

Therefore, it is crucial to take oral semaglutide on an empty stomach with only a small amount of water (less than 120 mL) and wait at least 30 minutes before eating or drinking anything else.

In summary:

  • Injections offer consistent and reliable absorption of semaglutide, regardless of food intake.
  • Oral semaglutide relies on specific conditions (empty stomach, limited water) for potentially good absorption, but can be significantly impacted by food.

It’s important to consult with a healthcare professional to determine the most appropriate form of semaglutide based on individual needs and circumstances. They can provide detailed instructions regarding administration and potential interactions with food and other medications.